The Effects of Nephrogenic Systemic Fibrosis

Nephrogenic Systemic Fibrosis, or Nephrogenic Fibrosing Dermopathy as it is otherwise known, is a disease that appears to affect mainly the skin. But, it can also lead to many other complications such as contractures, restriction of movement, and in some cases, even death.

Effects of Nephrogenic Systemic Fibrosis Relating to the Skin

Nephrogenic Systemic Fibrosis is sometimes known as Nephrogenic Fibrosing Dermopathy due to its symptoms that are particularly related to the skin, and which are most common to the disease. This includes tightening and hardening of the skin, as well as the skin appearing either redder or darker. It also develops plaques, and may feel “woody” and develop an “orange peel” texture. These symptoms are usually limited to the extremities, though at times they may also appear on the trunk of the body.

Nephrogenic Systemic Fibrosis May Lead to Contractures and Restriction of Movement

In addition to the effects on the skin, nephrogenic systemic fibrosis may also lead to contractures caused by the skin thickening, inhibiting flexion and extension of joints. This, in some cases, will lead to overall movement restriction and perhaps even the inability to walk.

Effects of Nephrogenic Systemic Fibrosis Which May Lead to Death

Nephrogenic Systemic Fibrosis itself is not really a cause of death, but the restriction of movement caused by it could lead to falls that could be complicated, or restrict effective breathing.

The effects of Nephrogenic Systemic Fibrosis are mainly related to the skin and NFS is therefore also often called Nephrogenic Fibrosing Dermopathy. These symptoms include a hardening, tightening, and discoloration of the skin of the extremities, and occasionally the trunk. The tightening and hardening of the skin however, can also lead to contractures and restriction of movement, and if this affects the breathing, then could result in death.

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Have you been diagnosed with NSF (Nephrogenic Systemic Fibrosis) or NFD (Nephrogenic Fibrosing Dermopathy)? Yes No
When and where was the diagnosis made?
When did your problems start?

Describe your symptoms and how they developed.
Did you have an MRI (Magnetic Resonance Imaging) or MRA (Magnetic Resonance Angiography) scan done before your symptoms began? Yes No
Where and when was the scan (or scans, if more than one) done?
Did you have kidney failure, kidney function deficiency, or other kidney problems at the time the scan (or scans) were done? Yes No
Describe the kidney problems you had.
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