Home : Medical Devices : Gadolinium & Nephrogenic Systemic Fibrosis (NSF) : Wikipedia : Gadopentetic acid

Wikipedia - Gadopentetic acid

  (Redirected from Magnevist)
Gadopentetic acid
Systematic (IUPAC) name
2-[bis[2-[carboxymethyl-(2-oxido-2-oxoethyl)amino]ethyl]amino]acetate; gadolinium( +3) cation; (2R,3R,4R,5S)-6-methylaminohexane-1,2,3,4,5-pentol
Identifiers
CAS number 86050-77-3
ATC code V08CA01
PubChem CID 55466
DrugBank DB00789
Chemical data
Formula C28H54GdN5O20 
Pharmacokinetic data
Half-life Distribution half life 12 minutes, elimination half 100 minutes
Therapeutic considerations
Pregnancy cat.  ?
Legal status

Gadopentetic acid (in the form of gadopentetate dimeglumine or Gd-DTPA) is the first paramagnetic magnetic resonance imaging (MRI) contrast agent. First described in 1981, and introduced in 1988, it is used to assist imaging of blood vessels and of inflamed or diseased tissue where the blood vessels become 'leaky'. It is often used when viewing intracranial lesions with abnormal vascularity or abnormalities in the blood-brain barrier. It is usually injected intravenously. Gd-DTPA is a gadolinium complex of diethylenetriamine pentaacetic acid and is classed as an acyclic, ionic gadolinium contrast medium. Its paramagnetic property reduces the T1 relaxation time (and to some extent the T2 and T2* relaxation times) in NMR, which is the source of its clinical utility.

Marketed as Magnevist by Bayer Schering Pharma, it was the first intravenous contrast agent to become available for clinical use, and is in widespread use around the world. Similar contrast agents are Dotarem (gadoterate) manufactured by Guerbet, MultiHance (gadobenate dimeglumine) and ProHance (gadoteridol) manufactured by Bracco, Omniscan (gadodiamide) manufactured by GE Healthcare, and OptiMARK (gadoversetamide) manufactured by Mallinckrodt.

Gadolinium based agents may cause a toxic reaction known as Nephrogenic Systemic Fibrosis (NSF) in patients with severe kidney problems.[1][2]

[edit] References

  1. ^ Murphy KJ, Brunberg JA, Cohan RH (1996). "Adverse reactions to gadolinium contrast media: a review of 36 cases". American Journal of Roentgenology 167 (4): 847–849. PMID 8819369. 
  2. ^ H.S. Thomsen, S.K. Morcos and P. Dawson (November 2006). "Is there a causal relation between the administration of gadolinium-based contrast media and the development of nephrogenic systemic fibrosis (NSF)?". Clinical Radiology 61 (11): 905–906. doi:10.1016/j.crad.2006.09.003. PMID 17018301. 

[edit] External links

v â€¢ d â€¢ e
Contrast media (V08)
X-ray
Iodinated,
Water-soluble
Nephrotropic,
high osmolar
Nephrotropic,
low osmolar
Metrizamide Â· Iohexol# Â· Ioxaglic acid Â· Iopamidol Â· Iopromide Â· Iotrolan Â· Ioversol Â· Iopentol Â· Iodixanol Â· Iomeprol Â· Iobitridol Â· Ioxilan
Hepatotropic
Iodinated,
Non-water-soluble
Non-iodinated
MRI
Other
Ultrasound
#WHO-EM. ‡Withdrawn from market. CLINICAL TRIALS: †Phase III. §Never to phase III
Stub icon This pharmacology-related article is a stub. You can help Wikipedia by expanding it.
Retrieved from "http://en.wikipedia.org/wiki/Gadopentetic_acid"

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Gadopentetic acid".

Find a Gadolinium & Nephrogenic System Fibrosis (NSF) Lawyer Now

This form is secure and encrypted. More information about secure forms and your privacy here.
* Required Fields

PERSONAL INFORMATION
First Name: *
Last Name: *
Address:
City:
State:
Zipcode:
Phone: -- ext.
Work Phone: -- ext.
E-mail Address: *

CASE INFORMATION
Have you been diagnosed with NSF (Nephrogenic Systemic Fibrosis) or NFD (Nephrogenic Fibrosing Dermopathy)? Yes No
When and where was the diagnosis made?
When did your problems start?

Describe your symptoms and how they developed.
Did you have an MRI (Magnetic Resonance Imaging) or MRA (Magnetic Resonance Angiography) scan done before your symptoms began? Yes No
Where and when was the scan (or scans, if more than one) done?
Did you have kidney failure, kidney function deficiency, or other kidney problems at the time the scan (or scans) were done? Yes No
Describe the kidney problems you had.

Need A Gadolinium & Nephrogenic Systemic Fibrosis (NSF) Attorney?

First Name Last Name Email Address State
Has Your Health Been Negatively Affected?

Please describe how you have been affected.

Your Friend's Email Address

Your Email Address

Type a Message (optional)


Want to contact a Gadolinium & Nephrogenic Systemic Fibrosis (NSF) lawyer in Washington, DC? ...Get a free case evaluation from one of our Gadolinium & Nephrogenic Systemic Fibrosis (NSF) lawyers in Washington, DC now.

 

Close (x)

Looking for an Attorney?


Please type your question:

Close (x)

logo Find Legal Help for Your Gadolinium & Nephrogenic Systemic Fibrosis (NSF) Case - Submit Your Information Below

Do you need legal assistance with your Gadolinium & Nephrogenic Systemic Fibrosis (NSF) case?
LegalView may be able to help.


Submit your information below for a free, no-cost evaluation.

We'll submit your information to one of our partner firms.
LegalView's partners represent clients throughout the United States, for a very wide range of legal issues. Submit your information now, to see if one of LegalView's partners can help!
* Required Fields

PERSONAL INFORMATION
First Name: *
Last Name: *
Address:
City:
State:
Zipcode:
Phone: -- ext.
Work Phone: -- ext.
E-mail Address: *

CASE INFORMATION
Have you been diagnosed with NSF (Nephrogenic Systemic Fibrosis) or NFD (Nephrogenic Fibrosing Dermopathy)? Yes No
When and where was the diagnosis made?
When did your problems start?

Describe your symptoms and how they developed.
Did you have an MRI (Magnetic Resonance Imaging) or MRA (Magnetic Resonance Angiography) scan done before your symptoms began? Yes No
Where and when was the scan (or scans, if more than one) done?
Did you have kidney failure, kidney function deficiency, or other kidney problems at the time the scan (or scans) were done? Yes No
Describe the kidney problems you had.
This form is secure and encrypted. More information about secure forms and your privacy here.